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> home > Products > Primary Antibodies > Antibody Collections > Druggable G protein-coupled receptors (GPCRs) > P2RY8 / P2Y8 Antibody (Cytoplasmic Domain)
P2RY8 / P2Y8 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q86VZ1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | IHC-P (2-4 µg/ml) |
| Gene ID | 286530 |
|---|---|
| Other Names | P2Y purinoceptor 8, P2Y8, P2RY8 |
| Target/Specificity | Human P2RY8 / P2Y8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR174 (41%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | P2RY8 / P2Y8 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RY8 {ECO:0000303|PubMed:30842656, ECO:0000312|HGNC:HGNC:15524} |
|---|---|
| Function | G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain (PubMed:11004484, PubMed:15466006). Expressed in B cells and follicular helper T cells in germinal centers (at protein level) (PubMed:30842656). |
| Volume | 50 µl |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Probable receptor for purines coupled to G-proteins.
References
Ross M.T.,et al.Nature 434:325-337(2005).
Adrian K.,et al.Biochim. Biophys. Acta 1492:127-138(2000).
Cantagrel V.,et al.J. Med. Genet. 41:736-742(2004).
Wollscheid B.,et al.Nat. Biotechnol. 27:378-386(2009).
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$ 467.50
Cat# ALS10466
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